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Neuro Center

Brain tumor in children

Children brain tumor is another tumor that is often found in children. It can be found since the child is 1 year old; however, it is usually found in children under the age of 7 years old. There is no clear collection of statistic in Thai, but, in the United States, there are 2,200 new children brain tumor cases each year. More boys are affected with brain tumor than girl.

Causes
There have been numerous studies and it was found that there may be numerous causes such as changes in the structure of some genetic chemical, which can be inherited, or due to changes in the environment. Currently, there is no clear cause; however, there have been progress. The continue study would result in more successful brain tumor treatment in the future.

Symptoms
Different brain tumor locations may result in different symptoms. If the tumor were in the motor control area, the child may not be able to stagger and fall easily. Other symptoms are weakness arm and legs, numbness in half of the body, squinted eyes, eye spasm, hazelip, seizure or spasm. The symptoms would increase if the tumor grows more or fast, which would cause high pressure in the brain. In little children, the symptoms must be observed since they are unable to express the symptoms such as depression, not able to suck milk and vomiting. When the children are older, they may be able to say that they have a headache. Additionally, high pressure in the brain also affects eye nerves. If it pressure were persistent, the eyesight may be loss or may result in loss of consciousness or comatose. From asking and examining, physician may be able to diagnose the tumor; however, it must be confirmed by CT scan or MRI, which will show the tumor along with the details of the size and location.

Treatment
Currently, there are numerous treatment techniques such as surgery, radiation and chemotherapy. In each case, neurosurgeon and pediatrician will provide information on the appropriate treatment since the brain tumor with different sizes will respond differently to different treatments. If large tumors were in location that is possible for surgery, surgery would be done. The advantage of surgery is the tumor can be removed immediately resulting in immediate brain pressure reduction.

Additionally, the tumor can be analyzed by pathologist enabling the patient to know the type of the tumor, which is very important because some tumors may require additional treatment such as radiation or chemotherapy[y after the surgery for more successful result of the treatment. The disadvantage of surgery is the risks that associate with surgery, which neurosurgeon would be able to inform the patient of the risks for each case. In some cases, the tumor is in a deep location or high risk is expected from surgery. If the tumor were no larger than 3 centimeters, Radiosurgery may be selected as the treatment.

Generally, the treatment result depends on many factors such as the patient condition prior to the surgery, the type of the tumor, whether it were or were not cancerous, how much of the tumor is removed by surgery, and if there were or were no complication. In the case of cancerous tumor, the treatment result is usually unsatisfactory because the cancer can reappear or spread to other areas.

In the case of cancerous tumor, radiation, or in some cases chemotherapy, is required after the surgery in order to yield better result.

Radiation is not the treatment for children under 2 years of age due to the affect of the radiation to the brain; therefore, chemotherapy technique is used. In the event that the tumor were non-cancerous, if the tumor were completely removed in surgery, there is a chance for being completely heal. If the tumor reappeared, it would be in the same location and can be removed again by surgery. Most of the time, there is no need for radiation or chemotherapy treatment after surgery. There are 3 types of brain tumor in children.

1. Pilocytic astrocytoma
Pilocytic astrocytoma usually appears in cerebellum as shown in the picture. This type of tumor is treated with surgery. If the tumor were completely removed, it may never reappear. Additionally, there is no need for radiation or chemotherapy[y treatment after surgery. However, there must be CT scan examination periodically to monitor if there would be new tumor.


X-ray picture of Pilocytic astrocytoma

In the cases that there is new tumor, it can be removed by surgery. The surgeries that are being today apply the usage of microscope, which will magnify different area resulting in being safer and more successful result. However, there are increased risks from surgery, especially when removing large tumor, which is usually attached to the brainstem.

2. Medulloblastoma
Medulloblastoma usually appear near cerebellum and rapidly grow and may spread to the cerebrospinal fluid. Additionally, the larger tumor may depress the cerebrospinal fluid resulting in brain fluid leading to more sever symptom. In some cases, the symptoms rapidly grow worst and surgery to place a fluid release pipe may be needed prior to the removal. As much of the tumor as possible needs to be removed and follow by radiation and in some cases, chemotherapy may be required. Currently, the treatment could enable the patient to stay alive for up to 10 years.


X-ray picture of Medulloblastoma

3. Brain stem Glioma
Brain stem Glioma grows rapidly because it appears in the very important area, the brainstem resulting in severe symptoms and the patient may rapidly get worst. This type of tumor cannot be treated by surgery; however, surgery may be necessary in some cases since there are high risks associated with brainstem surgery. Therefore, it was not treated with surgery in the past. However, there are equipments that help make the surgery safer such as Laparoscope and navigator that indicates the location during surgery. This type of tumor does not respond to radiation or chemotherapy treatment. The forecast is usually unreliable.


X-ray picture of Brain stem Glioma

The surgeries that are being today apply the usage of microscope, which will magnify different area resulting in being safer and more successful result. However, there are higher risks for the surgery, especially the large tumor that are attached to the brainstem.