รอบรู้เรื่อง ICSI เพิ่มโอกาสการตั้งครรภ์ คู่ไหนบ้างที่เหมาะ?

<p style="padding-top: 20px;">Many people are probably more familiar with the term <span style="color: #00826a;"><strong>ICSI (Intracytoplasmic Sperm Injection)</strong></span> than the term in vitro fertilization <span style="color: #00826a;"><strong>(In Vitro Fertilization: IVF)</strong></span>. However, ICSI is only a step in the fertilization process between the egg and sperm during IVF. In this method, the doctor selects a high-quality sperm under a microscope and injects that sperm directly into the egg cell. ICSI increases the chance of obtaining embryos by up to 90% compared to the traditional IVF method, where eggs and sperm are mixed together naturally.</p>
<h2><span style="color: #00826a;">Advantages of ICSI</span></h2>
<ul>
<li>Increases the chance of obtaining more embryos, especially for couples with sperm quality issues.</li>
<li>Reduces contamination of the feeder cells when couples need to screen for genetic diseases using NGS or Next Generation Sequencing, a technology that can detect chromosomal abnormalities.</li>
<li>Increases the chance of pregnancy due to more embryos being obtained in cases with poor sperm quality.</li>
</ul>
<h2><span style="color: #00826a;">What problems does ICSI help with?</span></h2>
<ul>
<li>Male problems with poor sperm quality or infertility.</li>
<li>Female problems such as advanced age, where eggs may have difficulty fertilizing naturally, or issues with the fallopian tubes, such as previous surgery or blockage.</li>
<li>Cases where couples have undergone traditional IVF but have low fertilization rates or no fertilization.</li>
<li>Couples who need to screen for genetic diseases using NGS (Next Generation Sequencing).</li>
</ul>
<h2><span style="color: #00826a;">Common risk factors for failure</span></h2>
<ul>
<li>Egg quality, which may be affected by ovarian stimulation in older women, as egg quality tends to decline with age.</li>
<li>Sperm quality, so if sperm quality is poor, consultation with a doctor is recommended before starting the ICSI process.</li>
<li>Embryo quality, which usually depends on the quality of the eggs and sperm.</li>
</ul>
<h2><span style="color: #00826a;">The ICSI procedure involves several steps similar to general IVF, which are:</span></h2>
<ul>
<li>Screening to find causes of infertility and diseases that may affect the child in the future.</li>
<li>Ovarian stimulation with hormone injections.</li>
<li>Egg retrieval process.</li>
<li>ICSI procedure.</li>
<li>Embryo culture for 5-6 days and NGS or Next Generation Sequencing testing, a technology that can detect chromosomal abnormalities.</li>
<li>Fresh embryo transfer into the uterine cavity.</li>
<li>Embryo freezing.</li>
<li>Preparation of the uterine cavity for frozen embryo transfer.</li>
</ul>
<p>The average success rate of ICSI across all age groups of couples is approximately 40-50%. Younger age groups have higher success rates, while older age groups have lower success rates. The main reason for lower success may be due to genetic abnormalities in the embryos.</p>
<p>Therefore, genetic screening of embryos using NGS may increase the success rate by another 20-30%. In cases where the uterus is normal or healthy, the success rate can increase up to 80%.</p>
<p>&nbsp;</p>
<p style="text-align: right;"><span style="color: #00826a;"><strong>Dr. Teerayut Jongwutiwes</strong></span><br />
<span style="color: #000000;">Reproductive Specialist</span><br />
<span style="color: #000000;">Infertility Treatment Center, Phyathai 2 Hospital</span></p>


ICSI or Intracytoplasmic Sperm Injection is a procedure for fertilization between an egg and sperm, where the doctor selects high-quality sperm under a microscope and injects it into the egg cell to increase the chances of obtaining a higher quality embryo.

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All About ICSI: Increasing Pregnancy Chances Which Couples Are Suitable?

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